|
KMID : 0616120170480040314
|
|
Korean Journal of Pharmacognosy
2017 Volume.48 No. 4 p.314 ~ p.319
|
|
|
Lifespan-extending Effects of Allium hookeri Leaves in Caenorhabditis elegans
|
|
Ki Byeol-Hui
Lee Eun-Byeol
Kim Jun-Hyeong
Yang Jae-Heon
Kim Dae-Keun
Kim Young-Soo
|
|
|
Abstract
|
|
|
|
To evaluate the longevity property of Allium hookeri (Liliaceae) leaves, this study was performed. Ethanol extract of A. hookeri was successively partitioned as methylene chloride, ethyl acetate, n-butanol and H2O soluble fractions, and lifespan-extending effects of the fractions were checked using Caenorhabditis elegans model system. The most active ethyl acetatesoluble fraction elevated heat stress tolerance, and increased expression of stress resistance protein. Further studies were performed to investigate several aging-related factors such as reproduction, food intake, growth and movement of C. elegans. The results revealed that there were no significant changes in aging-related factors including reproduction and food intake, however, ethyl acetate-soluble fraction treatment led to up-regulation of locomotory ability and growth of aged worms, suggesting ethyl acetate-soluble fraction affected healthspan as well as lifespan of nematode.
|
|
|
KEYWORD
|
|
|
Allium hookeri, Caenorhabditis elegans, Longevity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|